Roscoff (Brittany), France

Conférences Jacques-Monod - Retrograde signalling from endosymbiotic organelles

15.10.2018 - 19.10.2018

Retrograde signalling from endosymbiotic organelles - It has become increasingly apparent that the endosymbiotic organelles of eukaryotic cells, plastids, including chloroplasts, and mitochondria, are highly integrated into cellular signalling networks. In both heterotrophic and autotrophic organisms, plastids and/or mitochondria require extensive organelle-to-nucleus communication in order to establish a coordinated expression of their own genomes with the nuclear genome that encodes the majority of the components of these organelles. This goal is achieved by the use of a variety of signals that inform the rest of the cell about the number and developmental status of the organelles and their reaction to changing external environments. Such signals have been identified in both photosynthetic and non-photosynthetic eukaryotes (known as retrograde signalling and retrograde response, respectively) and, therefore, appear to be universal mechanisms acting in eukaryotes of all Kingdoms. In particular, chloroplasts and mitochondria both harbour crucial redox reactions that are the basis of eukaryotic life and are therefore particularly susceptible to stress from the environment, which they signal to the rest of the cell. These signals are crucial for cell survival, life span and environmental adjustment, and include quality control and targeted degradation of dysfunctional organelles, metabolic adjustments, developmental signalling as well as induction of apoptosis. The functional similarities between retrograde signaling pathways in autotrophic and non-autotrophic organisms are striking, suggesting the existence of common signalling mechanisms. In this meeting, we will bring together researchers from a wide range of experimental systems to try for the first time to build a bridge between these different research areas. By discussing commonalities and differences in the signaling mechanisms, we hope to develop our understanding of retrograde signaling as a general signaling mechanism in eukaryotic cells.

Deadline for application : July 4, 2018

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