Plants are frequently challenged by pathogens, but are often resistant due to the activation of their defense mechanisms. Generally, plant survival and growth are key to their productivity and thus important for agricultural crop yield. In many cases, however, the activation of the plant immune system is associated with reduced growth. This is pronounced in autoimmune mutants that are highly resistant but show dwarfism. Having non-transgenic methods to allow sufficient immunity without compromising growth and development would make important contributions to food security. Developing easy ways to apply such methods would serve farmers the best. We thus aim at separating growth deficit from resistance by identifying chemical compounds that can be applied to stimulate growth without limiting plant immunity. This will be done by high-throughput chemical genetics screening and be followed by compound optimization.